Exosomes · homing · p-exosome
AI-CODE Autologized Induced Conditioning of Oriented Exosomes
AI-CODE is an approach developed by Prof. Dr. H. Eray Copcu to direct regenerative exosomes to where they are needed. A very potent, non-autologous exosome is trained with the patient's own exosomes, which carry the homing signals of damaged tissue, and so induced toward the target.
The “AI” stands for Autologized Induced, not artificial intelligence.
- Autologous signal
- The patient's Exoplasma, via MNP
- Cargo
- Potent, non-autologous exosomes
- Conditioning
- Ex vivo, in FibriTrap
- Aim
- Homing to the damaged tissue
- Model
- Purposeful induction, as in iPSC
- Stage
- Patient's exosomes
- Potent exosomes
- Conditioned exosome
- Damage signal
Conceptual model, schematic.
“In regenerative medicine, where we direct it now matters as much as what we give.”
Exosomes
From cellular waste to the language of cells.
Exosomes are 30 to 150 nm across. Once regarded as cellular waste, they are in fact a main means of communication between cells, and one of today's most discussed subjects: a paradigm shift in regenerative medicine and surgery.
- Exosome 30–150 nm
- Platelet 2–3 µm
- Red cell 7–8 µm
- Fat cell ≈ 100 µm
A new concept
First in the literature: the p-exosome.
Prof. Copcu's group has defined, for the first time in the literature, a new concept: the p-exosome. p-Exosomes are programmed exosomes of plasmatic origin whose effect has been proven, and they have serious advantages over other exosomes.
Programmed
Directed to target cells by specific instructions.
Plasmatic
Obtained from the body's own regenerative fluid, plasma.
Proven
Only exosomes whose effect has been demonstrated count as p-exosomes.
Potent
A concentrated cargo with high activity.
Precision · peak performance · personalized
Homing
Giving is not enough: it has to arrive.
One of the most important ideas in regenerative medicine is that a product must be directed to the relevant area to give the result it is meant to. This is called homing. Damaged tissues and disrupted systems release exosomes with a homing effect into the circulation.
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Damaged tissue sends a signal
Hypoxia and inflammation, DAMPs and alarmins, cytokines (IL-1β, IL-6, TNF-α), chemokines (CXCL12/SDF-1, CCL2/MCP-1, CXCL8/IL-8) and angiogenic signals such as VEGF. The pattern depends on the tissue and the stage of injury.
- 2
Circulating cells and vesicles sense it
Subsets that carry CXCR4 can respond to the CXCL12 gradient; integrins, selectins and ICAM-1/VCAM-1 take part in adhesion; the plasma protein corona can change biodistribution. It is orientation in context, not exact targeting.
- 3
Local retention and response
Receptor–ligand engagement, passage through the endothelium and local adhesion. The vesicles' cargo then modulates the cells' response: angiogenesis, matrix remodelling and resolution of inflammation, depending on dose, preparation and microenvironment.
Method
Training the exosome with the patient's signal.
The exosomes that damaged tissue releases into the circulation, the autologous ones, are obtained and mixed with non-autologous exosomes. As in iPSC technology, this gives an induction toward a purpose.
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Autologous Exoplasma
From the patient's blood, via MNP: the patient's own platelet vesicles, carrying homing-related cues such as CXCL12/SDF-1, CCL5, PDGF and VEGF.
- 2
Potent, non-autologous exosomes
Exosomes from a strong source, such as umbilical cord blood: a regenerative cargo with angiogenic and immunomodulatory signals.
- 3
Autologized conditioning
The two meet ex vivo in FibriTrap under controlled mechanical interaction: protein–protein and surface interactions and the protein corona, with the cargo kept or modulated.
- 4
Oriented exosomes
Conditioned exosomes, oriented toward a damage-related regenerative response: homing, cell migration, angiogenesis and modulation of inflammation.
Like iPSC, for exosomes
In iPSC technology a cell's fate is induced in the laboratory. In AI-CODE it is the exosome's interaction context that is conditioned, ex vivo, with the patient's own signals.
| Cell-derived vesicles (iPSC/iMSC) | AI-CODE | |
|---|---|---|
| Setting | Cell-culture laboratory | Ex vivo, closed or semi-closed processing |
| Time | Days to weeks | Potentially the same session |
| Personalization | Depends on the donor or cell line | The patient's own plasma signal context |
| Evidence | Established research model | Translational hypothesis; validation required |
Stage
Where AI-CODE stands.
Prof. Copcu calls AI-CODE a revolution in regenerative medicine and surgery, because what matters now is not only what we give but where we direct it. It is being studied in hair regeneration and in ischemic tissue. It is not presented as a proven targeted therapy: it is a measurable, testable hypothesis of biological orientation, with this roadmap:
- 1
Particle profileNTA or equivalent
- 2
Vesicle markersCD9, CD63, CD81 and CD41/CD61
- 3
Protein cargoALIX, TSG101, cytokine profiling
- 4
MorphologyTEM or cryo-EM
- 5
FunctionCell assays, biodistribution, clinical correlation
Supply
Obtaining AI-CODE.
For supply and product information, contact:
Mest Sağlık Hizmetleri Tic. A.Ş.
Abdullah Ersu
+90 542 110 72 35Call · Abdullah ErsuLOGOS Pharma
Serkan Yüksel
+90 541 526 94 66Call · Serkan Yüksel
For scientific collaboration or a clinical question, write to Prof. Copcu.
Questions
Frequently asked questions.
What is AI-CODE?
AI-CODE (Autologized Induced Conditioning of Oriented Exosomes) is an approach developed by Prof. Dr. H. Eray Copcu in which potent, non-autologous exosomes are conditioned ex vivo with the patient's own exosomes, which carry homing signals from damaged tissue, so that they are induced toward the target.
Does the “AI” in AI-CODE mean artificial intelligence?
No. AI stands for Autologized Induced: the exosomes are autologized, that is conditioned with the patient's own signals, and induced toward a purpose.
What is a p-exosome?
A concept Prof. Copcu's group defined for the first time in the literature: programmed exosomes of plasmatic origin whose effect has been proven, with serious advantages over other exosomes.
What is homing?
The directing of a regenerative product to the area where it is needed. Damaged tissue releases signals such as the chemokine CXCL12/SDF-1, and cells and vesicles that carry the matching receptor, CXCR4, can follow that gradient.
How does AI-CODE relate to MNP?
The autologous signal in AI-CODE comes from the patient's Exoplasma, obtained via MNP (Mechano-Native Plasma), and the conditioning takes place in FibriTrap, the device developed with MNP.
Why is AI-CODE compared with iPSC technology?
In iPSC technology a cell is induced toward a new fate in the laboratory. AI-CODE applies purposeful induction to exosomes: the patient's own exosomes induce non-autologous exosomes toward the target, ex vivo and potentially in the same session.
Is AI-CODE a proven therapy?
It is in clinical study, in hair regeneration and ischemic tissue, and is presented as a testable hypothesis of biological orientation, not as a proven targeted therapy. Particle profile, vesicle markers, protein cargo, morphology and function are to be shown.
How can I obtain AI-CODE?
Contact Mest Sağlık Hizmetleri Tic. A.Ş. (Abdullah Ersu, +90 542 110 72 35) or LOGOS Pharma (Serkan Yüksel, +90 541 526 94 66).